Multifunctional low temperature-cured PVA/PVP/citric acid-based hydrogel forming microarray patches: Physicochemical characteristics and hydrophilic drug interaction

The characteristics of multifunctional polymeric hydrogel-forming microarray patches based on poly(vinyl alcohol)/poly(vinylpyrrolidone)/citric acid composite crosslinked at 80 °C were investigated. swelling study showed that this possesses a higher degree than the same polymer heated 130 due to lower crosslink density, which was then confirmed by FTIR examination. Solid-state studies revealed lower-temperature crosslinking does not provide enough energy for rearrange itself into crystalline form. However, shown possess acceptable mechanical strength insert/penetrate skin. patch can function both as means sample model hydrophilic drugs from skin and deliver them when combined with melt-type polyethylene glycol reservoir. interaction between hydrogel A drug diffusion coefficient, modelled theophylline (diffusion coefficient = 16.17 × 10-6 cm2/s), be delivered more efficiently fluorescent sodium 2.32 cm2/s) or cyanocobalamin 7.31 cm2/s). This is mainly theophylline’s high permeability (permeability 7.40 10-5 cm/s) weak ability interact (coefficient partitioning 1.3). These results indicated could useful predictive parameter determine delivery efficiency system. Furthermore, insight how select suitable monitoring involving compounds drug.